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Liver & Protein

Albumin

Albumin is the most abundant protein in blood plasma, synthesised exclusively in the liver. It maintains oncotic pressure (keeps fluid inside blood vessels), transports hormones, fatty acids, calcium, and many drugs, and acts as a buffer against oxidative damage. Serum albumin is one of the nine biomarkers in the Levine PhenoAge algorithm — falling levels are one of the strongest blood-based predictors of biological ageing.


Optimal Ranges

Clinical (NHS) Range

35-50 g/L

g/L

Performance-Optimised Range

42-48 g/L

g/L

The clinical range defines what is considered medically “normal” — broad enough to cover 95% of the population. The performance range reflects where research and clinical experience suggest most people feel and function at their best.


Why It Matters

Why Albumin matters for performance

Low albumin reflects two distinct things: reduced liver synthetic capacity, or systemic inflammation pulling protein into tissues. Either way, albumin tracks ageing closely — in the PhenoAge algorithm a 1 g/L drop adds roughly one biological year. Sustained levels above 45 g/L are associated with longer healthspan, better surgical outcomes, and lower all-cause mortality. Most healthy adults sit in the 40-50 g/L range; values below 38 g/L warrant investigation.


Symptoms

Signs your levels may be off

Low / Deficiency

  • Persistent ankle or eyelid oedema
  • Slow wound healing
  • Muscle loss disproportionate to diet
  • Fatigue and frequent infections
  • Frothy urine (if from kidney loss)

High / Excess

  • Usually indicates dehydration, not true elevation
  • May appear during diuretic use

Dietary Sources

Foods that support Albumin levels

Eggs (one of the highest-quality protein sources)Fish (salmon, cod, mackerel)Lean meats and poultryGreek yogurt and cottage cheeseLegumes and lentils

Supplementation

Evidence-based supplementation

Albumin itself is not supplemented; it is synthesised by the liver from dietary amino acids. Target 1.2-1.6 g of high-quality protein per kg of body weight daily, with leucine-rich sources spread across meals. Address inflammation and gut health if levels stay low despite adequate intake. Liver-supportive nutrients (choline, B vitamins, NAC) can support synthesis where liver capacity is the limiter.


Research

Key study

An epigenetic biomarker of aging for lifespan and healthspan

Levine ME, Lu AT, Quach A, et al.

Aging (Albany NY) (2018)

DOI: 10.18632/aging.101414

Related Biomarkers


Related Guides

Explore Albumin in depth


Test your Albumin levels

Albumin is included in the Helvy 50+ biomarker panel. Get your results in 5 days with a personalised protocol.

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This content is for educational purposes only and does not constitute medical advice. Your data suggests areas for optimisation, but any concerns should be discussed with a qualified healthcare professional. If your results flag values outside safe ranges, we recommend consulting your GP.