Helvy
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Hormones
In the UK, the standard clinical (NHS) reference range for Oestradiol (E2) is Cycle-dependent in women, 41-159 pmol/L in men, with Mid-cycle peak 500-1500 pmol/L (women); 70-150 pmol/L (men) considered the performance-optimised range. A result within these ranges suggests typical status; only a qualified clinician can interpret an individual reading.
Oestradiol (E2) is the primary form of oestrogen in non-pregnant adults, produced mainly by the ovaries in women and in much smaller amounts by the testes and peripheral conversion in men. It regulates the menstrual cycle, bone density, vascular function, mood, cognition, and skin elasticity. In men, oestradiol — converted from testosterone by aromatase — supports brain function, bone health, and libido at the right concentrations, but causes problems when elevated.
Optimal range · UK
Mid-cycle peak 500-1500 pmol/L (women); 70-150 pmol/L (men)
Performance-optimised band · clinical (NHS) range Cycle-dependent in women, 41-159 pmol/L in men
Clinical (NHS)
Cycle-dependent in women, 41-159 pmol/L in men
Performance
Mid-cycle peak 500-1500 pmol/L (women); 70-150 pmol/L (men)
Reference ranges for Oestradiol, not a personal result. Any individual reading should be interpreted by a qualified clinician.
Optimal ranges
| Range | Value |
|---|---|
| Clinical (NHS) reference range | Cycle-dependent in women, 41-159 pmol/L in men |
| Performance-optimised range | Mid-cycle peak 500-1500 pmol/L (women); 70-150 pmol/L (men) |
The clinical range defines what is considered medically “normal” — broad enough to cover 95% of the population. The performance range reflects where research and clinical experience suggest most people feel and function at their best. A result in either range suggests typical status and is not a diagnosis; any individual reading should be interpreted by a qualified clinician.
Why it matters
For women, oestradiol levels orchestrate the menstrual cycle and decline through perimenopause, driving symptoms like hot flushes, night sweats, mood changes, and bone loss. Tracking it alongside FSH and progesterone reveals where you sit in the perimenopausal transition. For men, the right oestradiol range is protective — too low is associated with low libido and joint pain, too high (often driven by visceral fat) with gynaecomastia, water retention, and reduced testosterone availability.
Symptoms
Low / Deficiency
High / Excess
Dietary sources
Supplementation
Do not supplement oestradiol directly. Address the regulatory inputs: body fat (particularly visceral, which is the main aromatase site), gut health (oestrogen recirculation), liver methylation (B6, B12, folate), and alcohol load. In perimenopause, HRT decisions belong to a GP — Helvy results provide the diagnostic context, not a prescription. Indole-3-carbinol (200-400 mg) and calcium-d-glucarate (500-1500 mg) are evidence-based options for oestrogen-metabolism support.
Testing
Oestradiol is measured from a blood sample. With Helvy, that means a finger-prick kit taken at home and posted to a UKAS-accredited UK laboratory, with results in around 5 days, reviewed by a qualified clinician. Your result is reported against both the clinical range (Cycle-dependent in women, 41-159 pmol/L in men) and the performance-optimal range (Mid-cycle peak 500-1500 pmol/L (women); 70-150 pmol/L (men)), so you can see not just whether you are “normal” but whether you are optimal. If you make a change, retest after 8-12 weeks to confirm it worked.
Research
Menopause and the postmenopausal woman: Cardiovascular and other concerns
Davis SR, Lambrinoudaki I, Lumsden M, et al.
Nature Reviews Endocrinology (2015)
DOI: 10.1038/nrdp.2015.4Related biomarkers
Related guides
This content is for educational purposes only and does not constitute medical advice. Your data suggests areas for optimisation, but any concerns should be discussed with a qualified healthcare professional. If your results flag values outside safe ranges, we recommend consulting your GP.
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